Mitotane (2,4′-DDD), Antineoplastic Agent

Mitotane (2,4′-DDD), an isomer of DDD and derivative of dichlorodiphenyltrichloroethane (DDT), is an antineoplastic agent, can be used to research adrenocortical carcinoma. Mitotane exert its adrenocorticolytic effect at least in part through lipotoxicity induced by intracellular free cholesterol (FC) accumulation. Mitotane can have direct pituitary effects on corticotroph cells. Mitotane can induce CYP3A4 gene expression via steroid and xenobiotic receptor (SXR) activation, and has agent-agent interactions. - Mechanism of Action & Protocol.

Mitotane, C14H10Cl4

Adrenocortical carcinoma: a clinician's update

Mitotane (Lysodren), Antineoplastic agents against adrenocortical carcinoma

Neoplasm and Antineoplastic Agents

Cancers, Free Full-Text

Mitotane Lipid Nanocarriers and Enantiomers

antineoplastic MedChemExpress (MCE) Life Science Reagents

Structural Requirements for Mitotane Activity: Development of Analogs for Treatment of Adrenal Cancer

Frontiers Synergistic Killing of Polymyxin B in Combination With the Antineoplastic Drug Mitotane Against Polymyxin-Susceptible and -Resistant Acinetobacter baumannii: A Metabolomic Study

Mitotane transformation to an active form. Adapted from reference (80).