Medicina, Free Full-Text

Background and Objectives: Orthostatic intolerance (OI) is a clinical condition in which symptoms worsen upon assuming and maintaining upright posture and are ameliorated by recumbency. OI has a high prevalence in patients with myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS). Limited data are available to guide the treatment of OI in ME/CFS patients. We and others have previously described patient-reported subjective improvement in symptoms using compression stockings. We hypothesized that these subjective reports would be accompanied by objective hemodynamic improvements. Materials and Methods: We performed a randomized crossover trial in 16 ME/CFS patients. Each underwent two 15-min head-up tilt table tests, one with and one without wearing knee-high compression stockings that provided 20–25 mm Hg compression. The order of the tests was randomized. We measured heart rate and blood pressure as well as cardiac output and cerebral blood flow (CBF) using extracranial Doppler of the internal carotid and vertebral arteries. Results: There were no differences in supine measurements between the 2 baseline measurements. There were no differences in heart rate and blood pressure at either end-tilt testing period. Compared to the test with the stockings off, the mean percentage reduction in cardiac output during the test with compression stockings on was lower, 15 (4)% versus 27 (6)% (p < 0.0001), as was the mean percentage CBF reduction, 14 (4)% versus 25 (5)% (p < 0.0001). Conclusion: In ME/CFS patients with orthostatic intolerance symptoms, cardiac output and CBF are significantly reduced during a tilt test. These abnormalities were present without demonstrable heart rate and blood pressure changes and were ameliorated by the use of compression stockings.

pub.mdpi-res.com/img/journals/medicina-logo-social

PubMed Central Article Datasets are Now Available on the Cloud - NCBI Insights

The COVID‐19 epidemic - Velavan - 2020 - Tropical Medicine & International Health - Wiley Online Library

Medicina, Free Full-Text

The best research databases for healthcare and medicine [Update 2024] - Paperpile

NATIONAL LIBRARY OF MEDICINE PubMed Central and the NLM Journal Archiving Vocabulary. - ppt download

Premium Yet Affordable Targeted transcutaneous electrical nerve stimulation for phantom limb sensory feedback, transcutaneous electrical nerve stimulation

Molecules, Free Full-Text, chinese wall cpa 20

OLLOIS Apis Mellifica 30c Organic, Lactose-Free Homeopathic Medicine, 80 Pellets (Pack of 5) : Health & Household

Medicina, Free Full-Text, bäumlein 108 led

Medicina, Free Full-Text