Drug-Like Molecules Regenerate Hair Cell-Like Cells in Adult Mice

“Think about a brake when driving a car,” Chen explains. “If the brake is always engaged, you can’t drive. We found an siRNA that could remove the brake in this genetic pathway.”

Hearing Health Foundation (HHF) is the largest non-profit funder of hearing research. Since 1958, HHF has given away millions of dollars to hearing and balance research, including work that led to cochlear implant technology and now through the Hearing Restoration Project is working on a cure for hearing loss and tinnitus. HHF also publishes Hearing Health magazine, a free consumer resource on hearing loss and related technology, research, and products.

Frontiers Research Progress on the Mechanism of Cochlear Hair Cell Regeneration

Highlights From the Hearing Restoration Project — Hearing Health

Researchers Discover Molecule Cocktail to Regenerate Hair Cells in Inner Ear

Generation of new hair cells by DNA methyltransferase (Dnmt) inhibitor 5-azacytidine in a chemically-deafened mouse model

Regenerated inner ear hair cells in mice provide new hope for those with hearing loss - Interesting Engineering

Stem Cell-Based Hair Cell Regeneration and Therapy in the Inner Ear

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Stem Cell-Based Hair Cell Regeneration and Therapy in the Inner Ear

Highlights From the Hearing Restoration Project — Hearing Health

PDF) Reprogramming by drug-like molecules leads to regeneration of cochlear hair cell-like cells in adult mice