Body size and risk of MS in two cohorts of US women
$ 13.00 · 4.9 (657) · In stock
Obese adolescents have an increased risk of developing multiple sclerosis (MS), and this result suggests that prevention of adolescent obesity may contribute to reduced MS risk. Objective: To examine whether obesity during childhood, adolescence, or adulthood is associated with an increased risk of multiple sclerosis (MS). Methods: Women in the Nurses’ Health Study (n = 121,700) and Nurses’ Health Study II (n = 116,671) provided information on weight at age 18 and weight and height at baseline, from which body mass index was derived. Women also selected silhouettes representing their body size at ages 5, 10, and 20. Over the total 40 years of follow-up in both cohorts combined, we confirmed 593 cases of MS. Cox proportional hazards models, adjusting for age, latitude of residence, ethnicity, and cigarette smoking, were used to estimate the rate ratios and 95% confidence intervals (CI). Results: Obesity at age 18 (body mass index ≥30 kg/m2) was associated with a greater than twofold increased risk of MS (multivariate relative riskpooled = 2.25, 95% CI: 1.50-3.37, p trend <0.001). After adjusting for body size at age 20, having a large body size at ages 5 or 10 was not associated with risk of MS, whereas a large body size at age 20 was associated with a 96% increased risk of MS (95% CI: 1.33-2.89, p trend = 0.009). No significant association was found between adult body mass and MS risk. Conclusions: Obese adolescents have an increased risk of developing multiple sclerosis (MS). Although the mechanisms of this association remain uncertain, this result suggests that prevention of adolescent obesity may contribute to reduced MS risk. 25(OH)D = 25-hydroxyvitamin D; BMI = body mass index; CI = confidence interval; MS = multiple sclerosis; NHS = Nurses’ Health Study; NHSII = Nurses’ Health Study II; RR = relative risk.
Why Do Young Women with Multiple Sclerosis Face Health Disparities
Risk factors in Multiple Sclerosis: Detection and Treatment in Daily Life
Epidemiology of pediatric multiple sclerosis: incidence, prevalence, and susceptibility risk factors (Chapter 3) - Demyelinating Disorders of the Central Nervous System in Childhood
Body-Mass Index and Mortality among 1.46 Million White Adults
Average Weight for Women by Age and Height
Building muscle with exercise: How muscle builds, routines, and diet
Childhood obesity and risk of pediatric multiple sclerosis and clinically isolated syndrome. - Abstract - Europe PMC
Investigating shared genetic architecture between obesity and multiple sclerosis
Why Young Women Are At Greater Risk Of Multiple Sclerosis
Epidemiology of pediatric multiple sclerosis: incidence, prevalence, and susceptibility risk factors (Chapter 3) - Demyelinating Disorders of the Central Nervous System in Childhood
The relative contributions of obesity, vitamin D, leptin, and adiponectin to multiple sclerosis risk: A Mendelian randomization mediation analysis - Adil Harroud, Despoina Manousaki, Guillaume Butler-Laporte, Ruth E Mitchell, George Davey Smith
Obesity and Multiple Sclerosis: A Mendelian Randomization Study
Woman diagnosed with MS at age 24 puts spotlight on
Epidemiology of pediatric multiple sclerosis: incidence, prevalence, and susceptibility risk factors (Chapter 3) - Demyelinating Disorders of the Central Nervous System in Childhood